According to the Market Statsville Group (MSG), the Global market for bone grafts and bone substitutes was rated at $2.5 billion in 2021 and should reach $3.5 million by 2030recording a CAGR of 4.3% from 2022 to 2030. Bone grafts are used in surgical procedures such as spinal fusion surgeries, bone replacement, new bone formation, and bone fracture repair. Additionally, bone grafting has applications in the treatment of various bone-related disorders such as congenital pseudarthrosis, dental bone grafting problems, and complex fractures. Allografts, synthetic bone grafts and demineralized bone matrix are the most commonly used bone grafts in the world.
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Global Bone Graft Substitute Market Expected to Be Driven by Urbanization and Rapid Growth in Industrialization. This ultimately led to an increase in the volume of waste from the industrial and municipal sectors. Additionally, increased environmental awareness and strict government standards have led to an increase in planned collection and disposal of waste.. Additionally, the growing concentration of smart city initiatives in both developed and developing countries is expected to enhance the global bone graft substitutes market.‘s growth in the years to come.
Rising incidence of musculoskeletal disorders, development of biocompatible synthetic bone grafts, and technological advancements in the medical field leading to shift from autograft to allograft are driving the growth of the bone grafts and substitutes market. For example, according to data published by the World Health Organization (WHO), in 2021 musculoskeletal disorders are the leading contributors to disability worldwide, with low back pain being the leading cause of disability in 160 countries or early deaths.
However, the high cost of surgeries, ethical issues with bone grafting procedures, and the negative impact of COVID-19 are expected to limit the market growth. However, increasing attention of key players towards R&D activities for bone grafts and substitute products has increased the demand for bone grafting procedures among the geriatric population. These are expected to provide lucrative opportunities for market players over the forecast period.
Global Bone Graft Substitute Market Definition
Bone grafts are implantable materials that promote bone healing through its osteoconductive, osteogenic and osteoinductive mechanisms.
Global Bone Graft Substitute Market Dynamics
Drivers: Development of biocompatible synthetic bone grafts
Biocompatible bone grafts do not encounter rejection problems from a host into which they have been incorporated. Thus, the development of biocompatible synthetic bone grafts is one of the major trends observed on the market. However, the development of biocompatible bone graft materials has reduced these failures and improved the rate of normal bone formation in hosts.
Additionally, biocompatible bone grafts have provided an excellent substitute for autogenous bone grafts. Moreover, the increase in demand for biocompatible grafts has increased the interest and efforts of companies to develop complete orthobiologic platforms.
Constraints: Ethical Issues Related to Bone Graft Procedures
Bone grafting involves the use of allografts and xenografts, which are transplanted from another donor of the same or different species and usually obtained from human and animal cadavers. The refusal rate for allograft gate procedures is observed at a high rate due to related ethical issues. For example, some countries do not support the use of cow and pig allografts. Also, some patients do not accept allografts from human remains.
Opportunities: Government regulations
Governments and regulatory bodies play an important role in accelerating or inhibiting the growth of any market. Each country has its own regulatory bodies with different regulations for food products, drugs, biological products, cosmetics, medical devices and other products related to human health. In addition, medical devices are specialized equipment that must be approved by the government for marketing.
Obtaining approval is a lengthy and expensive process, and is one of the major factors influencing market growth. Currently, bone grafts and substitutes are approved and marketed in the United States (FDA), Canada (Health Canada), European countries (CE mark), Japan (MHLW) and Australia (TGA).
Scope of the Global Bone Graft Substitutes Market
The study categorizes the Bone Graft Substitutes market based on product and application at regional and global level.
By Product Perspective (Sales, billion USD, 2017–2030)
- Machined allografts
- Demineralized bone matrix
- Bone graft substitutes
- Bone morphogenic proteins (BMP)
- Synthetic bone grafts
- Cell-based matrices
By Outlook app (Sales, billion USD, 2017–2030)
- spinal fusion
- Joint reconstruction
- Dental bone graft
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Outlook by region (Sales, billion USD, 2017–2030)
- North America
- The Netherlands
- Czech republic
- The rest of Europe
- Asia Pacific
- South Korea
- Australia and New Zealand
- Rest of Asia-Pacific
- South America
- Rest of South America
- The Middle East and Africa
- Saudi Arabia
- United Arab Emirates
- South Africa
- North Africa
- Rest of MEA
The segment of bone graft substitutes represents the largest market share, by product
By product, the market is further segmented into allografts, bone graft substitutes, and cell-based matrices. In 2021, bone graft substitutes were the largest market contributor. The increased need for bone grafting procedures has led to the development of several bone graft substitutes. Different types of bone graft substitutes are available in the market. These include calcium phosphate, calcium sulfate, collagen-based matrices, hydroxyapatite, tricalcium phosphate, and osteoinductive proteins.
Bone grafts have also emerged as a solution to all musculoskeletal disorders with emerging medical technologies. Major players have started to focus their efforts in the R&D of bone graft substitutes to meet the increased demands for bone grafts due to the increased prevalence of bone and joint disorders.
Asia Pacific represents the highest CAGR over the forecast period
On the basis of region, the global bone graft substitutes market has been segmented into North America, Asia–Pacific, Europe, South America, Middle East and Africa. Globally, Asia-Pacific is expected to hold the highest CAGR of 6.3% in the global bone graft substitutes market during the forecast period. The countries considered in the study are Japan, India, China, Australia, South Korea and the rest of Asia-Pacific. Japan accounts for the largest share of the bone graft and bone substitute market, followed by China.
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Synthetic bone graft substitutes are expected to be the most widely used bone graft substitutes in the Asia-Pacific market throughout the analysis period due to their proven benefits in patient medical history and relatively lower prices . Additionally, the adoption of allografts and BMPs is expected to increase in the region with recent approvals from regulatory agencies in countries like Australia and China. Rising overall healthcare spending in Asia-Pacific countries, such as India and China, is expected to drive the market growth in this region.
Leading Market Players in the Global Bone Graft Substitutes Market
The strategic analysis of top winning strategies is indicative, and information is gathered through press releases by top companies and is limited to publicly available information and primary appeals. The major players in the Bone Grafts and Substitutes market have adopted various strategies to gain additional market share. These strategies are gathered from press releases and annual reports from market players.
Medtronic was the leading company with a market share of 45.7% in 2021. It is the market leader in bone morphogenetic proteins and bone graft substitutes. The company offers a comprehensive portfolio of biologics, including INFUSE Bone Graft, Demineralized Bone Matrix (DBM) products and the Mastergraft family of synthetic bone graft products.
The main market players are:
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